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Other stimuli that enhance calcitonin secretion include supraphysiologic concentrations of glucagon (48), 5HT1 receptor agonists (49) gastrin (and pentagastrin) (50), alcohol (51), and exercise (52) and glucagon-like peptide-1 (GLP-1) (53) A detailed discussion of each of these stimuli is beyond the limits of this chapter and the reader is referred to a review on this subject for more detail (54) The finding that glucagon-like peptide-1 (GLP-1) agonists, an effective therapy for type 2 diabetes mellitus, bind to GLP-1 receptors, stimulates CT release and cause MTCs in rodents has stimulated a broad discussion regarding their safety in humans (53)

GLUCAGON-LIKE peptide-1 (GLP-1) receptor agonists use in patients with Type 2 diabetes is modestly associated with an increased rate of erectile dysfunction, a 2026 target trial emulation has found

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Adjuvant therapy continues for 15 weeks of combination therapy, with pembrolizumab continuing as a single agent for a total of 39 weeks