Through targeting long non-coding RNA [74] or the promoter region of the SCN1A gene with CRISPRa [75], the studies successfully increased SCN1A expression and restored dysfunctional neuron excitability and seizure phenotypes
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Circadian misalignment induced by disrupted lightdark cycles or genetic loss of NRF2 contributes to ROS accumulation and impaired activity of NRF2 and its target genes, including GCLC, GCLM, and Prdx3 (Lee et al
Standard GSH precursors such as NAC, which rely on endogenous synthesis, are ineffective in such models