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While glucose is a primary fuel source, the heart and skeletal muscles rely heavily on the oxidation of long-chain fatty acids for sustained energy

Ideal for replenishing fluid loss during training while promoting the proper functioning of lipid metabolism

By improving insulin sensitivity and reducing circulating glucose spikes, GLP-1 agonists also decrease the sugar-driven activation of immune cells that produce inflammatory cytokines

Overall, the mechanisms of semaglutide action can be described as a systemic, weight-focused intervention that targets caloric overload, insulin resistance, and pro-inflammatory adipokine profiles, all of which contribute to the liver pathology of MASH

However, no medication is completely risk-free