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[Multiple acyl-CoA dehydrogenase deficiency (MADD): a curable cause of genetic muscular lipidosis]
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According to 2023 CPIC pharmacogenomic guidelines, CYP2C19 poor metabolizers accumulate escitalopram at plasma concentrations equivalent to supratherapeutic doses in normal metabolizers, requiring a 50% dose reduction or an alternative antidepressant
Intracellular metabolites (GSH, glucose, glucose-6P, pyruvate, succinate) were measured by liquid chromatography (Vanquish HPLC Thermo Scientific) coupled to high resolution mass spectrometry (QExactive HF Thermo Scientific)
Our results emphasize the importance of the cellular context for modulation of the oxidative stress response by TGF-
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