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Figure 4 5.1 Hypothesis and its limitations Moreover, elevated levels of non-esterified fatty acids (NEFAs) in follicles can contribute to lipid toxicity, potentially leading to oxidative stress, mitochondrial dysfunction, and cellular damage, adversely affecting follicle and oocyte health ( in vitro fertilization (IVF) outcomes ( 5.2 Unlocking statistical power for IVF outcome assessment with PSM, self-control via skewed analysis Randomized treatment assignment achieved balance in both known and unknown confounding factors between treatment groups

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and HGC-27R-EVs-shVDAC1/PTX ( Figure 6A )

However, oral glutathione absorption is limitedstudies suggest only 518% reaches systemic circulation due to enzymatic degradation in the gastrointestinal tract