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Quick Answer: Cold sensations on tirzepatide result from weight loss reducing body insulation and metabolic rate, not from direct drug effects on temperature regulation

Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WHW, Bushman FD, Lusis AJ, Hazen SL (2013a) Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

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