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Furthermore, it should be noted that three recently discovered dimeric indole alkaloids namely 17-deacetoxycyclovinblastine, 14,15-didehydrocyclovinblastine, and 17-deacetoxyvinamidine along with five established compounds (vinamidine, leurosine, catharine, cycloleurosine, and leurosidine) exhibited in vitro viability inhibition against the human breast cancer cell line MDA-MB-231 with an inhibitory concentration ranging from 0.73 to 10.67 M (44)

Single-sample gene set enrichment analysis (ssGSEA) was performed to obtain a normalized enrichment score of ferroptosis-related metabolic pathways (Figs

It increases fibromyalgia severity, mainly central pain sensitization [81]

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