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These genes were shown to be overexpressed in several cancers [47] favouring cell migration and proliferation [48]

Phytochemicals including quercetin, beta-caryophyllene, curcumol, boswellic acid, caftaric acid, some flavonoids and other secondary metabolites being a consequential component of numerous medicinal plants, have displayed a significant reduction in the levels of proinflammatory cytokines including TNF-, NFB, IL-1, NLRP3 inflammasome, IL-6, IL-2, matrix metalloproteinases etc

Discussions and perspectives Limitations of current evidence, MASLD/ALD differences, and need for clinical translation This review summarizes the role of NAD + in regulating the accumulation of TG, oxidative stress, inflammation, ERS, and fibrosis in cases of fatty liver disease