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On the other hand, long-term exposure to high levels of thyroid hormones is associated with oxidative stress, which is related to depression-related neurodegenerative changes or even neuro-death in the brain (110)

Businger J, Fort AC, Vlisides PE, Cobas M, Akca O

In general, three major systems help to protect host cells from oxidative and nitrosative stress: (1) the superoxidase dismutase (SOD) and catalase system, (2) the glutathione system and (3) the thioredoxin system

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Bosch R, Philips N, Surez-Prez JA, Juarranz A, Devmurari A, Chalensouk-Khaosaat J, Gonzlez S