With supplementation, there was a small yet statistically significant increase in the risk of gestational hypertension (21.5% versus 19.4%, RR 1.11, 95% CI: 1.05-1.17) and term prelabor rupture of membranes (PROM) (9.6% versus 5.6%, RR 1.73, 95% CI: 1.34-2.23)
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Worse, degraded peptides can form aggregates or byproducts that may trigger immune responses or injection site reactions
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