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The closest human evidence in this drug class is not Dihexa at all

Nature Reviews Molecular Cell Biology, 16(7), 397408

Researchers found that, compared with healthy controls, the levels of trimethylamine oxide, glutamine, and lactic acid in the plasma of patients with depression were significantly increased, while the levels of phenylalanine, valine, alanine, glycine, leucine, citrate, choline, lipids, and glucose were significantly decreased

Antagonistic crosstalk between NF-B and SIRT1 in the regulation of inflammation and metabolic disorders

I point out that the confidence intervals for ALL outcomes cross 1 (null effect) which I interperet to mean the true effect could either be increased or decreased risk