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available evidence Metabolic shifts In animal models, Meldonium alters carnitine metabolism, decreases fatty-acid -oxidation, and increases glucose utilizationchanges that may be advantageous in hypoxic or ischemic conditions ( max and workload alongside an increased RER, suggesting impairedor at least not improvedmaximal performance ( Aerobic capacity and lactate Animal work reports reduced oxidative stress and sometimes lower lactate accumulation following Meldonium administration (65)

These findings align with previous studies that highlight the dose-dependent effects of antioxidants

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The mass spectrum with negative ionization mode for complex 1 after 1 min of incubation showed two signals at m/z = 229 and at m/z = 306, corresponding to the molecular masses of ferrocenecarboxylic acid and the GSH molecule, respectively