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Additional Phase III trials are ongoing to confirm these findings across broader populations

Studying GLP-1 + GIP + glucagon triple agonism in a single molecule retatrutide

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Currently, human clinical trials havent yet been established within the peer-reviewed literature. At present, most of the published evidence regarding this peptide falls within the first two categories

This narrative review aims to synthesize current evidence on the physiological and therapeutic relevance of GLP-1 signaling in sepsis, highlight mechanistic insights from preclinical studies, and assess the translational potential of GLP-1RAs in modulating systemic inflammation, metabolic dysregulation, and organ dysfunction in septic states