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The FDA determined the tirzepatide shortage resolved in late 2024 and the semaglutide shortage resolved in February 2025, and it set enforcement deadlines through 2025 for compounders to wind down shortage-based production

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This added mechanism improves insulin sensitivity and insulin secretory responses

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Some compounded formulations remain stable for 28 days after opening, while others have shorter windows

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AMPLITUDE-O Trial Investigators, Gerstein HC, Sattar N, Rosenstock J, Ramasundarahettige C, Pratley R, Lopes RD et al (2021) Cardiovascular and renal outcomes with efpeglenatide in Type 2 diabetes

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