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Safety, Tolerability and Sustained Weight Loss Over 2 Years With the Once-Daily Human GLP-1 Analog, Liraglutide

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Electronic Medicines Compendium (eMC) (2020) Meena et al

This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017

[DOI] [PubMed] [Google Scholar] 43.Garvey WT, Birkenfeld AL, Dicker D, et al