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Following apoptotic stimuli (e.g., DNA damage, growth factor deficiency), Bax/Bak forms oligomeric complexes that insert into the mitochondrial outer membrane, leading to changes in mitochondrial osmotic pressure

Other forms of primary liver disease can potentiate cirrhosis in patients with hemochromatosis with homozygous or heterozygous mutations.

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doi:10.1016/j.ajoc.2021.101171