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Secondly, the in vivo distribution and pharmacokinetics of these agents are complex, and clinical trials often encounter issues such as uneven drug retention and dose-limiting toxicities, which remain critical barriers to practical application (137, 138)

Quantitative analysis showed that the numbers of survived SGNs were reduced significantly in peroxynitrite-treated groups in a dose- and time-dependent manner compared with the control group (Figure 2B), that is, the higher concentration of peroxynitrite and the longer processing time induced more SGNs loss

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