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In clinical practice, a B1-B6-B12 injection may be considered when oral therapy is insufficient or not feasible, such as in malabsorption, severe deficiency, or when accelerated replenishment is desired under medical supervision

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Binding of glycolipids such as lyso-GB3 to TLR4 triggers NOTCH1 signalling, which subsequently activates the nuclear factor kappa B (NF-B) pathway