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The adaptor protein DDB1 (DNA damaging-binding protein 1) binds CULLIN4A/B-RBX1 complex and interacts with multiple WD40-repeat proteins (WDRs) to regulate cell cycle progression and DNA damage response 8

89 Interaction with non-coding RNAs (ncRNAs) ncRNAs and lactylation have been recently reported to mutually regulate each other in transcriptional processes

While effective in rats, this delivery method is unlikely to be practical or scalable in clinical longevity settings

Subsequently, we will elucidate the effect of iron overload on the pathophysiology of MDS and AML, clinical consequences of the altered iron metabolism and its use as a potential target for therapy

HES1 is a key downstream target of Notch signalling pathway, which regulates fibroblast activation and collagen release 13,14