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In patients with T2D, human amylin is known to accumulate in the pancreatic islets of Langerhans, forming oligomer aggregates that contribute to beta-cell damage in T2D
One study found that nearly half of users stopped treatment within a year, while another, focused on non-diabetic adults with obesity, reported just 32% remained adherent after 12 months
Approval was backed by the ATTAIN program, including ATTAIN-1 (n= 3127), where Foundayo showed weight loss of 27.3 lbs (12.4%) vs 2.2 lbs (0.9%) with PBO at the highest dose, with overall loss of 25 lbs (11.1%) vs 5.3 lbs (2.1%), alongside reductions in CV risk markers across all doses About Foundayo (orforglipron) Foundayo is a once-daily small molecule (non-peptide) oral glucagon-like peptide-1 receptor agonist that can be taken any time of the day without restrictions on food and water intake
The result is a system where traditional pharma is hyper-regulated for transparency and risk disclosure, while digital-first startups can operate with influencer-style freedom
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