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A special discussion has been undertaken in relation to a risk for acute pancreatitis and other pancreatic disease, since an increased risk of these diseases have been observed during incretin therapy in some studies (124, 125)

The freckles arising on the nose and cheeks of young children following sun exposure are due to localised increase in melanin production from normal melanocytes

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Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR (2018) Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

Regular bloodwork every three to six months helps monitor metabolic improvements and catch any unexpected changes early