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ROS stimulates the activity of many physiological components, including mitogen-activated protein kinases (MAPK), tyrosine kinases, Rho kinases, and transcription factors (NF-kB, AP-1, and HIF-1) and increased concentration of intracellular free Ca 2+ also inactivates the protein tyrosine phosphatases (PTP)

doi: 10.3390/ph16101507

Chalifour A, Jeannin P, Gauchat J-F, Blaecke A, Malissard M, N'Guyen T, Thieblemont N, Delneste Y: Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers a-defensin production

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