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Second, in humans with loss-of-function variants in SLC22A1, which decrease the uptake of metformin into the liver, the ability of metformin to lower A1c levels is not impaired (48)

Radiation-induced hypopituitarism is dose-dependent

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performed a systematic review and meta-analysis of GLP-1-based therapies on MASLD/MASH outcomes, incorporating both clinical trials and real-world studies [63]