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In these latter cases, a betaine and/or methionine supplement should be given in combination with folinic acid or 5-methylTHF (Table 2)

On 4 separate days, the patients received metformin (1,500 mg) or placebo suspended in a liquid meal, with subsequent i.v

Here, we have utilized liver-specific overexpression of cation transport regulator homolog 1 (Chac1), a recently identified intracellular GSH-degrading enzyme, to induce hepatic GSH depletion during MASLD progression

Cervantes-BarraganLChaiJNTianeroMDDi LucciaBAhernPPMerrimanJet al

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