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In contrast to the secretion and mRNA expression of t-PA, the secretion and gene expression of type 1 plasminogen activation inhibitor in human endothelial and smooth muscle cells is enhanced by homocysteine (Midorikawa et al, 2000)

doi: 10.1038/s41591-024-02964-1 190 HagenMBucciLBoltzSNothlingDMRotheTAnoshkinKet al

146 In a randomized controlled trial with 56 participants, taking 500 mg evening primrose oil twice daily for six weeks reduced menopausal hot flash severity, but not frequency or duration, more than placebo

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