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The color of the dot represents the FDR (q-value) levels (B) Volcano plot of DEGs in the GSE96851 dataset (C) Venn diagram of the common upregulated DEGs in GSE14668 and GSE96851 (D) Venn diagram of the common downregulated DEGs in GSE14668 and GSE96851 (E) Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of upregulated DEG (F) GO enrichment analysis and KEGG pathway analysis of downregulated DEGs (G) Gene set enrichment analysis (GSEA) revealed the pathways enriched with upregulated DEGs (H) GSEA revealed the pathways enriched with the downregulated DEGs

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Some patients experience a brief return of nausea after escalating

Calibrate: What Sets Them Apart

Common side effects (usually when starting or increasing the dose): Nausea, vomiting, diarrhea, constipation Abdominal pain or discomfort Reduced appetite (helpful for weight loss but can feel uncomfortable) These occur because the medication slows gastric emptying, making you feel full faster