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Here, well look at some of the studies concerning cancer and snus

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This research has, however, some limitations including that it uses self-reported data susceptible to social desirability biases, that it is cross-sectional and thus does not allow for causal inference, that it is subject to residual confounding, and that it was conducted using only US data, which limits its generalizability for adult LCC users in other countries

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Freebase nicotine is alkaline, though, and it tends to irritate the throat at high nicotine strengths