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Inhibiting TRPM7 increases CHOP and calpain expression and increases apoptosis in RA-FLS cells in vitro (93)

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Investigations with animal model induced to intense and exhaustive aerobic exercise protocols or, in situations of high catabolism, such as sepsis, show that chronic supplementation with DIP or with glutamine and alanine in their free forms is efficient for the supply of glutamine to the body, which can attenuate biomarkers of injury and inflammation after periods of intense training, as well as attenuate the inflammatory response induced by long-term exercise [142]