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Without enough glutathione, mercury can damage the brain and also take the place of selenium in certain biological pathways.[ref] Related article : Mercury, detoxification, and your genes Alcohol: Acute or chronic alcohol exposure leads to a depletion of glutathione in the liver and liver damage

Fortunately, there are several effective ways to increase glutathione in the body

H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)

The effect of glutathione is limited and thereby it has to be maintained

doi: 10.3389/fphar.2021.663325 269 DengXLiYJiangLXieXWangX