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Someone who is anorexic is much more likely to have a heart attack and far more likely to have cholesterol issues because of that condition. A few other situations dont rule you out automatically, but they do call for extra caution and a real conversation: a history of gallbladder disease, diabetic retinopathy (rapid weight loss can temporarily make it worse), and any history of an eating disorder, which warrants screening before treatment starts

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Extensive in vitro pharmacological characterization of the active peptides revealed that P5 displayed comparable efficacy to the endogenous ligand GLP-1 and its analogue Ex4 with regards to G-protein signalling