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Next, the model was further validated in a Gene Expression Omnibus (GEO) cohort and functional enrichment analysis was performed to explore the possible mechanisms of these identified genes in different risk groups classified using the developed model

Clinically, liver injury manifests as a sharp rise in transaminases, abnormal bilirubin metabolism, and coagulation dysfunction, often combined with damage to the heart, brain, kidneys, and other organs, constituting MODS

Diagnosis is made by measuring the concentration of different metabolites in the -glutamyl cycle and homocysteine, enzyme activity, and/or mutation analysis