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Combination or staged GLP-1 with nutrition therapy Given the existing adherence and cost challenges of GLP-1s coupled with significant weight regain after discontinuation, combination or staged therapy with intensive lifestyle management could promote greater efficacy, cost-effectiveness, and equitable obesity care [3,18,222,[271], [272], [273]]

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Some advanced protocols use 5 days on, 2 days off to provide periodic receptor recovery windows, though the evidence for superiority over continuous daily dosing is limited to anecdotal reports rather than controlled trials

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Therefore, the new Wegovy weight loss pill may appeal to far more people who are suitable for the drug and wanting an effective medication to use alongside their weight management plan