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Statements Acknowledgments Work in our laboratories is supported by ERDF-cofinanced grants from the Ministry of Science and Innovation (BIO2012-33904 and BFU2011-22779)

Antioxidant effects prevent skin oxidation, enhance radiance, and are used to improve dark spots, melasma, and dullness

The most important marker is Insulin-like Growth Factor 1 (IGF-1)

The fact that oxidative stress, mitochondrial problems, lipids, fatty acid metabolism, female hormones and gender all showed up suggests the field is getting at some core issues in ME/CFS and long COVID

Diagnosis is confirmed using molecular testing methods and/or experiments to examine the deficient enzyme