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The cysteine that is S-nitrosylated is found to reside in a consensus motif I/L-X-C-X2-D/E, where X refers to any amino acid

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The FDA determined the tirzepatide shortage resolved in late 2024 and removed semaglutide from its shortage list in February 2025, then set wind-down deadlines after which large-scale compounding of essentially-a-copy of these drugs was no longer permitted (FDA)