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While Melanotan II activates all five melanocortin receptor subtypes, PT-141 was designed to preferentially target MC3R and MC4Rthe receptors most involved in sexual responsewhile minimizing activation of MC1R (responsible for tanning) and MC5R

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Further comparative studies with PAP therapy are also warranted to establish optimal treatment strategies and better define patient selection criteria

The analysis adjusted for numerous baseline covariates, including age, sex, race, weight-related factors (e.g., obesity) and key comorbidities such as renal disease, cerebrovascular disease and congestive heart failure

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