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Importantly, comorbid T2DM or elevated peripheral IR accelerate disease progression in AD and PD independently of vascular disease, with higher peripheral IR predicting conversion from mild cognitive impairment to AD (12, 13) and faster motor and cognitive decline in PD (14, 15), thereby implicating IR as a modifier of NDD biology rather than a simple comorbidity

2010;5(9) View abstract

First, it may secrete toxins or cell wall-associated molecules that directly damage epithelial cells and disrupt tight junctions, resulting in increased permeability of the intestinal barrier 137