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For most people, these are temporary and mild, but understanding them helps in managing expectations and safety, according to the World Health Organization

doi:10.1016/S0306-4522(97)00347-3 Waugh WH

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Numerous inflammatory mediators, including tumor necrosis factor-alpha (TNF-), interleukins (IL-1, IL-6, IL-18), matrix metalloproteinases (MMPs), chemokine ligand 2 (CCL-2), monocyte chemoattractant protein-1 (MCP-1), nuclear factor kappa B (Nf-B), transforming growth factor-beta (TGF-), E-selectin, various adhesion molecules (ICAM-1, VCAM-1), toll-like receptors (TLRs), adiponectin, endothelial cell-selective adhesion molecule (ESAM), and interferon-gamma (INF-), are strongly implicated in diverse forms of diabetic complications [33], [34], [35]

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