For example, treatment of murine macrophages with GLP-1RAs in vitro inhibits monocyte chemoattractant protein-1 gene expression and p65 as well as tumor necrosis factor (TNF)- expression
The function of VDR depends not only on ligand binding with 1,25-dihydroxyVitamin D but also on its dynamic interactions with coactivators (e.g., SRC-1, DRIP205/MED1), epigenetic enzymes (e.g., HDACs, LSD1, PRMT5), and corepressor/de-repressor complexes (e.g., NCoR/SMRT), which are recruited and reorganized in a ligand-inducible manner to mediate precise gene regulation [113,114,115]
Kinnun JJ, Mallikarjunaiah KJ, Petrache HI, Brown MF (2015) Elastic deformation and area per lipid of membranes: atomistic view from solid-state deuterium NMR spectroscopy
Co-morbidities and mortality associated with transfusion-dependent -thalassaemia in patients in England: a 10-year retrospective cohort analysis
Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between