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Preclinical models have revealed that patients with deletion of Pgp have 100-fold increased sensitivity to chemotherapy agents and antiviral compounds in comparison to control subjects

While it is not clear how this translates to the kinetics of cAMP production in cells expressing individual receptors, the divergence in peptide responses across each receptor is consistent with the dynamic conformational differences that were observed structurally for individual AMYRs bound to distinct peptides

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This can significantly reduce or completely eliminate its biological activity, rendering your research material ineffective and wasting the product