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Japan's herbal cigarettes market was valued at USD 0.4 billion in 2024 and is expected to grow from USD 0.45 billion in 2025 to USD 0.65 billion by 2033, with a CAGR of approximately 4.8%
However, a high ROS state induces oxidative stress, leading to mitochondrial DNA (mtDNA) damage and membrane integrity disruption
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Furthermore, nicotine mediates therapeutic resistance, survival and antiapoptosis, and self-renewal of cancer stem cells and modulates many immune properties of cancer [12]
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