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A preliminary randomised controlled trial to compare the effects of duloxetine and acetyl-l-carnitine on pain, depression, anxiety, and well-being in patients with fibromyalgia suggested that acetyl-l-carnitine was efficacious in improving depressive symptoms, pain, and quality of life [91]
Enhanced Cognitive Function Patients often notice improvements in memory, focus, and cognitive clarity after starting B12 shots
doi: 10.1016/0278-6915(86)90172-9
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Some key trials: TRIUMPH-4 (obesity and osteoarthritis): Completed
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