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Oxidative Stress: Free radicals in smoke generate reactive oxygen species (ROS), causing cell death and tissue destruction

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In addition, as marijuana smoking is usually associated with deeper inhalation, longer breath-holding times, use of unfiltered marijuana cigarettes (joints) with a potential for greater delivery of tar to the lungs [47], and the marijuana smoke being even more cytotoxic and mutagenic [48, 49] in comparison with tobacco smoking