Various neurological conditions like anxiety, depression, dementia such as Alzheimers, and Parkinsons disorder are caused by an imbalance in this axis (263, 264)
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GSH is synthesized de novo in the brain by astrocytes and research has demonstrated increased GSH synthesis during oxidative stress-related toxicity in vitro , proposing in vivo synthesis of this antioxidant might be sufficient to not detect significant changes ( 4.2
Capitalizing on this understanding, nutritional interventions target OA through a multi-tiered approach: (1) Upstream regulation using anti-inflammatory nutrients (e.g., omega-3 fatty acids, polyphenols) to quell systemic inflammation and oxidative stress (10)
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