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While we have observed a direct detrimental effect of a cholesterol-enriched diet on islet GLP-1R cAMP outputs, we cannot rule out that the reduced receptor capacity to lower blood glucose levels following cholesterol loading might encompass further negative effects of high cholesterol on GLP-1R downstream signalling

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Characterization of recombinant wild type and site-directed mutations of apolipoprotein C-III: lipid binding, displacement of ApoE, and inhibition of lipoprotein lipase

The ZRT Laboratory Blog , Accessed May 30, 2022.