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65 Immune-Inflammatory Mechanisms: Systemic Low-Grade Inflammation and Mucosal Damage The gastrointestinal tract is not only the site of digestion and absorption but also the bodys largest immune organ, involved in immune responses and inflammatory processes

First, these medications significantly alter gastrointestinal function by slowing gastric emptying, which can lead to nausea, vomiting, and dehydrationall potential headache triggers

Hyperprolactinemia interferes with the activity of gonadotropin-releasing hormone (GnRH) neurons and is a recognized cause of functional hypogonadism ( At the central level, excessive prolactin inhibits the synthesis and pulsatile secretion of hypothalamic gonadotropin-releasing hormone (GnRH), thereby reducing the release of pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone, ultimately leading to hypogonadism ( In women, prolactin has a significant inhibitory effect on ovarian steroid production, leading to reduced synthesis and secretion of estradiol and progesterone ( In men, hyperprolactinemia is accompanied by hypogonadism and androgen deficiency, which can lead to unfavorable changes in the body composition

Details of treatments with GCLC siRNA, LC, and mRNA analyses are given previously (26)

This dual action, anti-inflammatory plus antimicrobial, addresses two of the three core eczema problems simultaneously