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doi: 10.3389/FDDSV.2022.1043617 237 TigasSTsatsoulisA
Insulin resistance & prediabetes, National Institute of Diabetes and Digestive and Kidney Diseases (2025) Efficacy and safety of once-weekly semaglutide 2.4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial, The Lancet Diabetes & Endocrinology (2024) With prediabetes, action is the best medicine, American Diabetes Association Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes2025, Diabetes Care (2025) About the Lifestyle Change Program, CDC (2024)
Neuroimaging studies with MRI and brain PET have shown correlations with these neuropsychological alterations and brain structural-functional alterations [5, 6]
Hypothalamic action of delta-9-tetrahydrocannabinol to inhibit the release of prolactin and growth hormone in the rat
It has a well-understood mechanism with a growing body of long-term safety data
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