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The major detoxification pathway of 4HNE involves GSTs 16
FASEB J (1998) 12:58192
M.KennyP
Thus, under asthmatic conditions, intracellular GSH levels could reflect not only the generation of reactive hydroperoxy-phospholipids by the 15LO1-PEBP1 complex, but also the compensatory levels and activity of GPX4, the availability of newly synthesized and regenerated GSH, as well as extracellular transport
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