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Studies show this leads to more regular cycles & improved pregnancy rates, both naturally & with IVF
For example, after GLP-1 binding the transmembrane helices 1 (TM1) rotates clockwise when looking down the membrane helices from the extracellular face (see TM1 marked in Figure 6) and a kink is introduced in the transmembrane helix 6 (TM6), as is typical for all class B1 GPCRs
Other drugs with potential anti-senescence effects are fluvastatin and valsartan, traditional medications used in cardiovascular diseases [132]
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