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Acid reflux itself happens when the lower esophageal sphincter (LES), the muscular valve between your esophagus and stomach, weakens or relaxes inappropriately, allowing stomach acid to splash back up

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The mean plasma homocysteine concentration, which was elevated at 10.8 mcmol/L at baseline, decreased by 39% in the active-treatment group (p=0.001 compared with the change in the placebo group)

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