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Neurology 80 , 16981701 (2013)

Moreover, some in vivo studies show that the peptide may actually reduce growth in tested animals due to the suppressive effect of this research peptide on the natural production of growth hormone

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To inactivate LS GLP-1R neurons, we injected AAV expressing double-floxed EGFP and TeNT (AAV-DIO-EGFP-2A-TeNT) into the bilateral LS of GLP-1R-ires-Cre mice to achieve specific expression of EGFP-2A-TeNT in LS GLP-1R neurons (Figure 3A and Supplemental Figure 6C)